Sale!

Buy THJ-2201 Online

$110.00$3,000.00

The widespread recreational use of synthetic cannabinoids (SCBs) represents a major public health issue, as reports of intoxications and deaths following SCB use rapidly mount up. Specifically, a direct link between SCB use and acute kidney injury (AKI) has been established, although the pathophysiologic mechanisms remain undefined. Here we assessed the in vitro nephrotoxicity of three commonly detected and structurally distinct SCBs – AB-FUBINACA, JWH-122 and THJ-2201 in human proximal tubule cells (HK-2), to ascertain potential similarities and/or differences regarding their nephrotoxicity signatures. We showed that two of the three SCBs tested, namely JWH-122 and THJ-2201, at in vivo relevant concentrations (1 nM – 1 μM), triggered apoptotic cell death pathways, mainly through a shared mechanism involving the deregulation of mitochondrial function (i.e. with mitochondrial membrane hyperpolarization and increased intracellular ATP levels), as the primary molecular signature of nephrotoxicity mechanism.

Clear
SKU: FT0863CH Categories: ,

Description

THJ-2201 is nothing but a synthetic cannabinoid analogue of AM-2201. THJ-2201 is known to work as a potent agonist for the peripheral CB2 and central CB1 receptors and the Ki values are of 2.6nM and 1.0nM respectively. In case of THJ-2201, the indazole group basically replaces the entire indole group. As far as the research chemical industry is concerned, THJ-2201 is known to fill a gap in the current cannabinoid scene. THJ-2201 is only allowed to be used as a research chemical only. So you cannot consume it under any circumstances, however, can buy the same for forensic or chemical analysis purposes.
The formal name of THJ-2201 is 1-[5-fluoropentyl)-1H-indazol-3-yl] (naphthalene-1-yl) methanone. On the other hand, the molecular formula of the same is C23H21FN2O. Please remember that AM-2201 is no longer available for research purposes in various parts of the world now. As a result, being an indazole analogue of AM-2201, THJ-2201 has found huge importance among chemical researchers. This research chemical is usually available in off white, high purity powder form. THJ-2201 is usually sold as a crystalline solid and the molecular mass of the same is set at 360.4 g/mol. Its effects on living beings are yet to be known properly though.
This study aimed to assess the single-dose toxicity of THJ-2201 by hematological and histopathological evaluation of liver and kidney specimens in Swiss albino mice. The experimental protocol included oral treatment of mice with different doses (5, 50, 300, 2000 mg/kg body weight of THJ-2201) for 24 h. At the end of the treatment, blood samples had been drawn, and renal and hepatic tissues have been excised from the experimental mice groups for hematological and histological examinations.
The administration of THJ-2201 in low and high preload doses brought about severe clinical symptoms, including tachycardia, convulsions, and difficulty in breathing. Further, an increase in locomotor activity of mice was also observed. Severe constriction and stiffness were observed for all muscles of the body. Similarly, narrowing of the eyes and prominent blood vessels in the ears were observed. There were deaths after dosage ranging from 1 to 24 h; however, the animals which survived exhibited normal behavior, similar to the animals in the control group. The toxicity was observed to be a dose-dependent phenomenon. The LD50 value was calculated to be 822.20 mg/kg .

Additional information

options

10 g, 100 g, 1000 g, 25 g, 250 g, 50 g, 500 g