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Dimethocaine and structurally related local anesthetics such as cocaine and procaine inhibit the uptake of dopamine (DA) by blocking dopamine transporters(DAT).The dopamine transporter controls the dynamics of the neurotransmitter dopamine.

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DIMETHOCAINE, also known as DMC or larocaine, is a compound with a stimulatory effect. This effect resembles that of cocaine, although dimethocaine is addictive due to its stimulation of the reward pathway in the brain. However, dimethocaine is a legal cocaine replacement in some countries and is even listed by the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) under the category “synthetic cocaine derivatives”.The structure of dimethocaine, being a benzoic ester acid, resembles that of  procaine. It is found as a white powder at room temperature.
Cocaine and other local anesthetics are known to produce cardiotoxicity by blocking sodium channels.However, no reports have been published of these same effects of cardiotoxicity associated with dimethocaine.There has been little research about toxicity of dimethocaine in humans, and therefore the exact lethal or pharmacological doses are unknown.Dimethocaine is often abused as a legal substitute for cocaine. The drug is administered intravenously or nasally, because ingestion would lead to rapid hydrolyzation.It’s positive effects are euphoria, stimulation, increased talkativeness and mood lift. However, because the drug acts similar as cocaine, it has comparable negative side effects. These side effects include:tachycardia, difficulty with breathing, pain on the chest, vasoconstriction,insomnia,paranoia and anxiety.Dimethocaine probably poses larger health issues than cocaine. This is due to the fact that more dimethocaine must be administered to produce the same euphoric feeling, resulting in larger risk for the negative effects.
There are user reports that confirm unpleasant effects on the heart. Dimethocaine (DMC, larocaine), a synthetic derivative of cocaine, is a widely distributed “legal high” consumed as a “new psychoactive substance” (NPS), originally was used in the 1930s as an anesthetic, primarily in dentistry, ophthalmology, and otolaryngology. This drug completely inhibits dopamine transporter and has had the potential for abuse. Dimethocaine is intended for forensic and research purposes.

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