ISONIAZID is used with other medications to treat active tuberculosis (TB) infections. It is also used alone to prevent active TB infections in people who may be infected with the bacteria (people with positive TB skin test). Isoniazid is an antibiotic and works by stopping the growth of bacteria.
Isoniazid preventive therapy (IPT) for tuberculosis in pregnant women with HIV was associated with excess adverse pregnancy outcomes and may warrant a reassessment of the current World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC) guidelines, according to a poster presented at CROI 2018, held from March 4-7 in Boston, Massachusetts.
Primary outcome was reached in 15% of women (74 in the immediate/antepartum group vs 73 in deferred/postpartum group) with an incidence rate of 15.4/100 person-years and 14.9/100 person-years, respectively. There were no statistically significant differences in incidence rates of any maternal grade ≥3 adverse events (30% vs 28%), all-cause hepatotoxicity (6% vs 7%), or infant grade ≥3 adverse events (43% vs 41%) between the 2 groups. There was also no difference in maternal tuberculosis or infant tuberculosis between the 2 groups. However, adverse pregnancy outcomes were higher in the immediate/antepartum vs deferred/postpartum group (23% vs 17%; =.009).