TRENTAL Active Ingredient: Pentoxifylline Trental is indicated for the treatment of patients with intermittent claudication on the basis of chronic occlusive arterial disease of the limbs.
At the first signs of an anaphylactic/anaphylactoid reaction,Trental must be discontinued and a physician must be informed.
Patients with hepatic impairment should be closely monitored during Trental therapy and may require lower doses. Since Trental (pentoxifylline is extensively metabolized in the liver, the use of this drug is not recommended in patients with severe hepatic impairment of liver function (Child-Pugh class C, score > 9).
Patients with renal impairment (creatinine clearance below 80 mL/min) should be closely monitored during Trental therapy and may require lower doses. Since Trental (pentoxifylline) is eliminated through the kidneys, the use of this drug is not recommended in patients with severe renal impairment (creatinine clearance below 30 mL/min).
Pentoxiflline belongs to the group of medications called vasoactive agents. These medications work by improving blood flow in the arms and legs.Pentoxifylline is used to treat chronic circulation disorders of the arms and legs, such as intermittent claudication (peripheral arterial disease) or ulcers due to poor blood supply. It may allow further distances to be walked before leg pain or cramps occur. It may take up to 2 months to see the full benefits of the medication.
The usual recommended adult starting dose of pentoxifylline is 400 mg twice daily after meals. Your doctor may adjust the dose over time as needed to a maximum of 400 mg 3 times daily. The tablets must be swallowed whole – do not crush or chew the tablets.
Many things can affect the dose of medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here,do not change the way that you are taking the medication without consulting your doctor.
It is important to take this medication exactly as prescribed by your doctor. If you miss a dose, take it as soon as possible and continue with your regular schedule. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.Do not take a double dose to make up for a missed one. If you are not sure what to do after missing a dose, contact your doctor or pharmacist for advice.
Store this medication at room temperature, protect it from light and moisture, and keep it out of the reach of children.