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Duloxetine, sold under the brand name CYMBALTA among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, and neuropathic pain. It is taken by mouth.

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CYMBALTA is the brand name for duloxetine, an antidepressant prescribed to treat the symptoms of depression. In addition to depression, doctors can prescribe Cymbalta to treat anxiety that lasts for at least six months, pain from diabetic nerve damage, fibromyalgia, and long-term muscle or bone pain.
Cymbalta is the brand name for duloxetine, an antidepressant prescribed to treat the symptoms of depression.
In addition to depression, doctors can prescribe Cymbalta to treat anxiety that lasts for at least six months, pain from diabetic nerve damage, fibromyalgia, and long-term muscle or bone pain.
Cymbalta is in a class of medications called serotonin-norepinephrine reuptake inhibitors (SNRIs).
It works by increasing the levels of the neurotransmitters serotonin and norepinephrine, which help regulate mood and may block pain signals traveling through the brain.
The Food and Drug Administration (FDA) approved duloxetine in 2004 under the brand name Cymbalta for the Lilly drug company.
In 2013, the FDA announced that it had approved generic versions of duloxetine for several drug companies.
Cymbalta could also help ease pain associated with osteoarthritis, according to a study published in the International Journal of Clinical Practice in 2012.The researchers noted that use of Cymbalta could result in fewer side effects than the drugs traditionally used for the condition, such as non-steroidal anti-inflammatory drugs, or NSAIDs, which can lead to gastrointestinal bleeding, and opioids like morphine, which often lead to constipation.
They concluded that doctors may consider adding antidepressants, such as Cymbalta to the treatment regimens for patients with osteoarthritis.Cymbalta Suicide Warnings
The FDA requires that Cymbalta carry a black-box warning about the risk of suicide among people who use the antidepressant.
Cymbalta may increase the risk for suicidal thoughts or behaviors if you are 24 years old or younger. Doctors usually do not prescribe Cymbalta for anyone younger than 18.
The risk is greatest when first starting treatment or increasing the dose of Cymbalta.Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain).
Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.

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