BB-22 is an analog of JWH 018 that is structurally similar to PB-22 (Item No. 14096) and its derivative, 5-fluoro PB-22 (Item No. 14095). Both BB-22 and PB-22 are distinctive in that an 8- hydroxyquinoline replaces the naphthalene group of JWH 018. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications.
BB-22 is an analog of the potent synthetic cannabinoid, JWH 018 that is structurally similar to PB-22 and its derivative, 5-fluoro PB-22 Both BB-22 and PB->22 are distinctive in that an 8-hydroxyquinoline replaces the naphthalene group of JWH 018. BB-22 5-hydroxyisoquinoline isomer differs from BB-22 structurally by having the quinoline group replaced with an isoquinoline group attached at its five position. The physiological and toxicological properties of this compound are not known. This product is intended for forensic and research applications
Clandestine laboratories continue producing new synthetic cannabinoids that mimic and magnify natural cannabinoids effects to circumvent drug scheduling legislation. New synthetic cannabinoids are highly potent and responsible for many acute intoxications and deaths. Characterization of metabolic pathways is critical to identify metabolite markers whose detection can prove intake. BB-22 is a new potent synthetic cannabinoid whose toxicological and metabolic properties are currently unavailable. Analytical methods require constant updating and are challenging due to extensive synthetic cannabinoid metabolism and low marker concentrations. A single non-specific BB-22 metabolite was previously identified in incubations with human liver microsomes (BB-22 3-carboxyindole). Clear characterization of BB-22’s metabolism is required to help toxicologists document BB-22 consumption in clinical and forensic cases. We incubated 10 μmol/L BB-22 with cryopreserved human hepatocytes for 3 h. Samples were analyzed by liquid chromatography on a biphenyl column and high resolution mass spectrometry. Results were processed with data mining software, identifying ten metabolites. Loss of the quinolinyl side-chain via ester hydrolysis was the main biotransformation. All other metabolites were produced by further indole or cyclohexylmethyl .